Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice

RATIONALE: Drug reward plays a central role in acquiring drug-seeking behavior. However, subjects may continue using drugs despite negative consequences because self-administration becomes habitual, and divorced from outcome values. Although a history of drug and alcohol use expedite habit acquisition, and in spite of the fact that self-administration leads to intoxication, the acute effects of drugs on habitual responding are not well understood. OBJECTIVES: We sought to observe how acute ethanol and amphetamine affect the balance between habitual and goal-directed behavior, as measured by a fluid-reinforced operant conditioning task. METHODS: Selectively bred crossed high-alcohol-preferring (cHAP) mice were trained on an operant conditioning task reinforced on a variable interval schedule with 1% banana solution, which was subsequently devalued via LiCl pairing in half the animals. Ethanol (1.0 g/kg), amphetamine (2.0 mg/kg), or saline was administered prior to a post-devaluation test. RESULTS: Overall, mice showed habitual behavior, but when divided into high- or low-responding groups based on training response rates, saline-treated, low-responding animals devalued, while saline-treated high-responding animals did not. Furthermore, amphetamine elicited devaluation even in high-responding animals, while ethanol prevented devaluation even in low-responding animals. CONCLUSIONS: These data show that ethanol shifts animals toward behaving habitually. This may illuminate why alcohol-intoxicated individuals display impaired judgment about the relative merits of drinking, and potentially serve as a mechanism by which intoxicated subjects resume previously devalued behaviors, such as comorbid drug use. These findings also show that high variable interval response rates facilitate a shift from goal-directed to habitual behavior

A superconducting qubit with Purcell protection and tunable coupling

We present a superconducting qubit for the circuit quantum electrodynamics architecture that has a tunable coupling strength g. We show that this coupling strength can be tuned from zero to values that are comparable with other superconducting qubits. At g = 0 the qubit is in a decoherence free subspace with respect to spontaneous emission induced by the Purcell effect. Furthermore we show that in the decoherence free subspace the state of the qubit can still be measured by either a dispersive shift on the resonance frequency of the resonator or by a cycling-type measurement.Comment: 4 pages, 3 figure

Theoretical three-and four-axis gimbal robot wrists

In high-performance flight simulations, a four-axis gimbal system allows all possible rotations with acceptable gimbal angle rates while it avoids the so-callled 'gimbal lock' that occurs when gimbal rotational axes are colinear. In this paper, pertinent equations (including quaternions) are assembled for a hypothetical robot wrist, functionally equivalent to this four-axis gimbal system, and also for a true three-axis gimbal robot wrist. These equations are used to simulate the rotation of a robot hand by the robot wrist in response to operator rotational velocity commands to the robot hand. Near gimbal lock (wrist singularity), excessive rotational rates occur. Scaling the rates, which is necessary for the three-gimbal robot wrist to prevent rate limiting, introduces an undesirable time delay in the robot hand rotation with respect to the commanded rotation. However, the merit of the four-gimbal robot wrist is that the fourth gimbal angle keeps the robot wrist away from the singularity so that the robot hand moves exactly as commanded. It appears that in a 'worst-type' maneuver of the robot hand, the fourth gimbal angle can be defined so that none of the gimbal angle rates exceed about twice the commanded rates

Tunable coupling in circuit quantum electrodynamics with a superconducting V-system

Recent progress in superconducting qubits has demonstrated the potential of these devices for the future of quantum information processing. One desirable feature for quantum computing is independent control of qubit interactions as well as qubit energies. We demonstrate a new type of superconducting charge qubit that has a V-shaped energy spectrum and uses quantum interference to provide independent control over the qubit energy and dipole coupling to a superconducting cavity. We demonstrate dynamic access to the strong coupling regime by tuning the coupling strength from less than 200 kHz to more than 40 MHz. This tunable coupling can be used to protect the qubit from cavity-induced relaxation and avoid unwanted qubit-qubit interactions in a multi-qubit system.Comment: 5 pages, 4 figure

Simulation study of intracity helicopter operations under instrument conditions to category 1 minimums

A fixed-base simulator study was conducted to define pilot workload and task performance associated with instrument flight operations for an intracity helicopter passenger service. Displays considered necessary to provide a minimal capability under Instrument Flight Rules conditions were used to fly a representative commercial helicopter route structure in the New York area, with each terminal assumed to be equipped with a precision approach guidance system. A cross section of pilots participated as test subjects, and despite the high workload level, the results indicated that for the assumptions employed, minimums of 61 m (200 ft) ceiling and 805 m (0.5 mile) visibility were feasible

Kinematic rate control of simulated robot hand at or near wrist singularity

A robot hand should obey movement commands from an operator on a computer program as closely as possible. However, when two of the three rotational axes of the robot wrist are colinear, the wrist loses a degree of freedom, and the usual resolved rate equations (used to move the hand in response to an operator's inputs) are indeterminant. Furthermore, rate limiting occurs in close vicinity to this singularity. An analysis shows that rate limiting occurs not only in the vicinity of this singularity but also substantially away from it, even when the operator commands rotational rates of the robot hand that are only a small percentage of the operational joint rate limits. Therefore, joint angle rates are scaled when they exceed operational limits in a real time simulation of a robot arm. Simulation results show that a small dead band avoids the wrist singularity in the resolved rate equations but can introduce a high frequency oscillation close to the singularity. However, when a coordinated wrist movement is used in conjunction with the resolved rate equations, the high frequency oscillation disappears

Empirical comparison of a fixed-base and a moving-base simulation of a helicopter engaged in visually conducted slalom runs

Combined visual, motion, and aural cues for a helicopter engaged in visually conducted slalom runs at low altitude were studied. The evaluation of the visual and aural cues was subjective, whereas the motion cues were evaluated both subjectively and objectively. Subjective and objective results coincided in the area of control activity. Generally, less control activity is present under motion conditions than under fixed-base conditions, a fact attributed subjectively to the feeling of realistic limitations of a machine (helicopter) given by the addition of motion cues. The objective data also revealed that the slalom runs were conducted at significantly higher altitudes under motion conditions than under fixed-base conditions